The Oconee Nuclear Generating Station is a nuclear power plant located on Lake Keowee in Seneca, South Carolina, and has an energy output capacity of over 2,500 megawatts. It is the second nuclear power plant in the United States to have its operating license extended for an additional twenty years by the U.S. Nuclear Regulatory Commission (NRC) (the application for the Calvert Cliffs plant in Maryland preceded it).

Oconee Nuclear Generating Station has three Babcock and Wilcox pressurized water reactors, and is operated by Duke Energy.

Oconee was the first of three nuclear stations built by Duke Energy. According to Duke Energy's web site, the station has generated more than 500 million megawatt-hours of electricity, and is "the first nuclear station in the United States to achieve this milestone."

Oconee Nuclear Generating Station
Country	United States
Locale	Seneca, South Carolina
Status	Operational
Commission date	Unit 1: July 15, 1973 Unit 2: Sept. 9, 1974 Unit 3: Dec. 16, 1974
Licence expiration	Unit 1: Feb. 6, 2033 Unit 2: Oct. 6, 2033 Unit 3: July 19, 2034
Construction cost	~$500 million
Owner(s)	Duke Energy
Operator(s)	Duke Power
Architect(s)	Duke and Bechtel
Power generation information
Annual generation	20,565 GW·h
Net generation	>500,000