The Khmelnitskiy Nuclear Power Plant is a nuclear power plant in Netishyn, Khmelnytskyi, Ukraine. The plant is operated by Energoatom. Two VVER-1000 reactors are operational, each generating 1000 MW (net) of electricity. Construction of the first reactor started in 1981 and the first unit was put in operation in late 1987. Construction of the second reactor started in 1983 with plans to finish it in 1991. In 1990, however, construction was stopped as part of a moratorium on new plant construction. Construction was completed only in August 2004 after the moratorium was lifted.

Two reactors are currently under construction. Construction of the third reactor started in September 1985 and the fourth reactor in June 1986. Construction was stopped in 1990 when they were 75% and 28% complete, respectively. An intergovernmental agreement on the resumption of construction was signed between Ukraine and Russia in June 2010. On 10 February 2011, Energoatom and Atomstroyexport signed a contract agreement for the completion of reactors 3 and 4. They should be commissioned in 2016 and 2017, respectively. Feasibility study of reactors 3 and 4 was conducted by Kiev Institute Energoproekt.

Khmelnytskyi Nuclear Power Plant is the start of the 750kV-powerline Widelka-Khmelnytskyi, one of three 750 kV lines running from Ukraine to the European Union.